Steven M Holland Selected Research

Job Syndrome (Hyper-IgE Syndrome)

10/2020	STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations.
1/2016	Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.
11/2015	Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome.
1/2015	WU polyomavirus in respiratory epithelial cells from lung transplant patient with Job syndrome.
12/2013	Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation.
7/2013	Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome.
6/2013	Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism.
6/2013	Serum free light chains as predictors of lymphomagenesis in patients with autosomal dominant hyper-immunoglobulin E syndrome (Job's syndrome).
5/2013	Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm?
1/2012	Cutaneous manifestations of DOCK8 deficiency syndrome.

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Steven M Holland Research Topics

Disease

97	Infections 04/2022 - 05/2002
49	Chronic Granulomatous Disease 04/2022 - 03/2002
27	Job Syndrome (Hyper-IgE Syndrome) 10/2020 - 12/2004
20	Pneumonia (Pneumonitis) 01/2022 - 02/2004
16	GATA2 Deficiency 01/2022 - 09/2011
16	Neoplasms (Cancer) 01/2022 - 02/2004
14	Mycoses (Diseases, Fungus) 01/2022 - 06/2003
14	Inflammation (Inflammations) 01/2022 - 03/2002
14	Eczema 09/2017 - 01/2004
11	Reinfection 09/2017 - 03/2003
10	COVID-19 08/2022 - 10/2020
9	Tuberculosis (Tuberculoses) 01/2019 - 04/2006
8	Virus Diseases (Viral Diseases) 08/2022 - 11/2009
8	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021 - 12/2010
7	Pulmonary Alveolar Proteinosis 10/2021 - 02/2010
7	Coccidioidomycosis 01/2021 - 09/2009
7	Primary Immunodeficiency Diseases 01/2020 - 05/2008
6	Neutropenia 04/2022 - 12/2009
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 03/2010
6	Eosinophilia 05/2018 - 01/2004
6	Abscess 01/2018 - 12/2004
6	Colitis 01/2017 - 12/2010
6	Opportunistic Infections (Opportunistic Infection) 10/2015 - 12/2010
5	Bacterial Infections (Bacterial Infection) 04/2022 - 06/2003
5	Disease Progression 01/2022 - 12/2009
5	Chronic Mucocutaneous Candidiasis 01/2022 - 08/2010
5	Lymphopenia (Lymphocytopenia) 01/2022 - 01/2012
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 02/2014
5	Exanthema (Rash) 01/2012 - 06/2003
5	Scoliosis 05/2009 - 11/2005
4	Cytopenia 01/2022 - 02/2010
4	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 02/2014
4	Cryptococcosis 06/2021 - 03/2014
4	type 1 Autoimmune polyendocrinopathy syndrome 01/2021 - 12/2010
4	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 01/2021 - 08/2016
4	Liver Abscess 01/2018 - 03/2007
4	Inborn Genetic Diseases (Disease, Hereditary) 09/2017 - 01/2007
4	Hypertension (High Blood Pressure) 12/2014 - 10/2002
4	Autoimmune Diseases (Autoimmune Disease) 12/2013 - 02/2004
4	Immune System Diseases (Immune Disorders) 09/2013 - 09/2002
4	Dermatitis 01/2012 - 03/2004
3	Leukemia 01/2022 - 05/2010
3	Candidiasis (Moniliasis) 01/2022 - 12/2010
3	Thymoma (Thymic Carcinoma) 11/2021 - 12/2010
3	Nocardia Infections 11/2020 - 08/2002
3	Persistent Infection 01/2020 - 05/2006
3	Warts (Wart) 01/2019 - 04/2015
3	Periodontitis 10/2018 - 03/2014
3	Aspergillosis 01/2018 - 04/2004

Drug/Important Bio-Agent (IBA)

40	AutoantibodiesIBA 08/2022 - 10/2005
32	Immunoglobulin E (IgE)IBA 10/2020 - 01/2004
28	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2022 - 03/2002
21	CytokinesIBA 02/2022 - 02/2006
19	InterferonsIBA 08/2022 - 08/2005
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2004
16	Interferon-gamma (Interferon, gamma)IBA 01/2021 - 08/2002
15	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 04/2003
14	Interleukin-12 (IL 12)IBA 12/2019 - 09/2002
13	Anti-Bacterial Agents (Antibiotics)IBA 04/2022 - 03/2003
13	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 04/2016 - 03/2002
12	Superoxides (Superoxide)IBA 01/2019 - 03/2002
10	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 06/2021 - 02/2010
9	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 10/2003
9	NADP (NADPH)IBA 01/2020 - 03/2011
8	AntibodiesIBA 01/2021 - 12/2010
7	Immunoglobulin G (IgG)IBA 08/2022 - 06/2008
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 10/2003
7	STAT1 Transcription FactorIBA 01/2021 - 09/2002
7	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2018 - 12/2008
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2006
6	GATA2 Transcription FactorIBA 01/2022 - 04/2013
6	Oxidants (Oxidizing Agents)IBA 01/2022 - 03/2002
5	Busulfan (Busulfex)FDA Link 01/2022 - 12/2014
5	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2022 - 02/2006
5	AntigensIBA 01/2019 - 04/2008
5	Pharmaceutical PreparationsIBA 05/2018 - 05/2002
5	Interferon gamma ReceptorIBA 08/2013 - 09/2004
4	VaccinesIBA 11/2021 - 04/2014
4	Immunoglobulins (Immunoglobulin)IBA 05/2018 - 02/2010
4	NF-kappa B (NF-kB)IBA 01/2016 - 02/2004
4	Matrix Metalloproteinases (MMPs)IBA 09/2015 - 06/2003
4	EnzymesIBA 01/2015 - 04/2003
4	DNA (Deoxyribonucleic Acid)IBA 07/2013 - 04/2004
3	Messenger RNA (mRNA)IBA 08/2022 - 01/2017
3	Antiviral Agents (Antivirals)IBA 02/2022 - 12/2009
3	interleukin-21 (interleukin 21)IBA 01/2022 - 07/2014
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022 - 01/2020
3	Rituximab (Mabthera)FDA Link 01/2021 - 04/2012
3	Sirolimus (Rapamycin)FDA Link 01/2020 - 01/2014
3	InterleukinsIBA 12/2019 - 03/2010
3	Interleukin-23 (Interleukin 23)IBA 10/2018 - 03/2014
3	ChemokinesIBA 01/2018 - 10/2003

Therapy/Procedure

32	Therapeutics 04/2022 - 03/2003
14	Transplantation 04/2022 - 05/2004
13	Hematopoietic Stem Cell Transplantation 01/2022 - 06/2011
5	Cell Transplantation 04/2022 - 07/2019
5	Stem Cell Transplantation 01/2022 - 10/2003
5	Drug Therapy (Chemotherapy) 01/2017 - 12/2004
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2020 - 02/2015
4	Immunotherapy 01/2019 - 02/2006